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Mephedrone (4-MMC) is frequently used with alcohol. A mouse study looked at the interaction of these two medications, focusing on 4-MMC’s psychostimulant and reward properties. Low doses of liquor (non-energizer) significantly boosted the psychostimulant effects of 4-MMC. Because haloperidol, but not ketanserin, could inhibit potentiation by liquor, this effect was offset by an increase in synaptic dopamine. 4-MMC’s remunerating properties now include a minor, non-compensating amount of liquor.
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